持(chi)續近兩(liang)個多月的新型(xing)冠狀病毒感染的肺(fei)炎疫情牽動著每(mei)一個人的(de)心，為(wei)了打贏(ying)這場疫情防控狙(ju)擊(ji)戰(zhan)，搞清致病(bing)(bing)機(ji)理，研發抗病(bing)(bing)毒藥物和疫(yi)苗刻不(bu)容緩。Jena bioscience品牌有豐富的抗病毒核苷酸(suan)/核苷酸類(lei)似物，助力(li)抗(kang)病毒藥物研發。
抗病毒核苷及核苷酸類似物主要有:
抗病(bing)毒核苷(gan)/核苷(gan)酸類似物可以(yi)通(tong)過(guo)抑制(zhi)(zhi)病毒(du)復制(zhi)(zhi)的幾個(ge)關(guan)鍵過(guo)程來抑制(zhi)(zhi)病毒(du)繁殖，它(ta)們通過與(yu)天(tian)然的(de)dNTP/NTP競爭(zheng)結合到(dao)新的病毒核酸中，從而導致鏈(lian)終止或者誘變。在細胞培養(yang)實驗中，可以(yi)用抗病毒(du)核(he)苷酸(suan)的非磷(lin)酸(suan)化核(he)苷變體，這種(zhong)(zhong)核(he)苷酸(suan)在(zai)細(xi)胞內被多種(zhong)(zhong)病毒(du)和/或(huo)宿主(zhu)激酶(mei)激活，從而(er)發揮(hui)(tri)磷酸化形式的(de)抗病毒作(zuo)用。
熱銷抗病毒核苷/核苷(gan)酸(suan)類似物：
|
品牌 |
貨號 |
品名 |
規格 |
|
Jena Bioscience |
NU-1605S |
3TCMP |
10 μl (10 mM) |
|
Jena Bioscience |
NU-1605L |
3TCMP |
5 x 10 μl (10 mM) |
|
Jena Bioscience |
NU-1606S |
3TCTP |
5 μl (10 mM) |
|
Jena Bioscience |
NU-1606L |
3TCTP |
5 x 5 μl (10 mM) |
|
Jena Bioscience |
NU-1603S |
d4TMP |
20 μl (10 mM) |
|
Jena Bioscience |
NU-1603L |
d4TMP |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
NU-1601S |
AzTMP |
20 μl (10 mM) |
|
Jena Bioscience |
NU-1601L |
AzTMP |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
NU-989S |
AzTTP |
10 μl (100 mM) |
|
Jena Bioscience |
NU-989L |
AzTTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-875 |
ara-Adenosine-5'-monophosphate (ara-AMP) |
2 mg |
|
Jena Bioscience |
NU-1111S |
50 μl (10 mM) |
|
|
Jena Bioscience |
NU-1111L |
ara-Adenosine-5'-triphosphate (ara-ATP) |
5 x 50 μl (10 mM) |
|
Jena Bioscience |
NU-876 |
Acyclovir-5'-monophosphate |
2 mg |
|
Jena Bioscience |
NU-877 |
Acyclovir-5'-triphosphate |
2 mg |
|
Jena Bioscience |
NU-021-2 |
Ribavirin-5'-monophosphate |
2 mg |
|
Jena Bioscience |
NU-1105S |
20 μl (10 mM) |
|
|
Jena Bioscience |
NU-1105L |
Ribavirin-triphosphate |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
N-DN-8234-100 |
β-L-2'-Deoxythymidine |
100 mg |
|
Jena Bioscience |
NU-896S |
10 μl (100 mM) |
|
|
Jena Bioscience |
NU-896L |
6-Aza-UTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-974 |
Tenofovir |
100 mg |
|
Jena Bioscience |
NU-975 |
Tenofovir-diphosphate |
1 mg |
|
Jena Bioscience |
NU-989S |
10 μl (100 mM) |
|
|
Jena Bioscience |
NU-989L |
AzTTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-275S |
10 μl |
|
|
Jena Bioscience |
NU-275L |
Ganciclovir-triphosphate |
5 x 10 μl |
西美杰(jie)是Jena bioscience中國總代(dai)理，為用戶提供完(wan)善的技術(shu)與(yu)售后服(fu)務。如對產品感興趣歡迎(ying)撥打西美(mei)杰客(ke)服(fu)熱(re)線400-050-4006了解詳(xiang)細信息。西美杰會更好的協助科研工作(zuo)者(zhe)的實驗工作(zuo)，支持(chi)全國戰“疫”，早日戰勝病毒。武(wu)漢加油(you)！中國(guo)加油(you)！
參考(kao)文(wen)獻(xian)：
1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18.
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740.
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154.
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34.
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375.
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press.
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.
